Pharmacological Effects of Curcumin in Chronic Inflammatory Therapy
DOI:
https://doi.org/10.62872/r1y2wm33Keywords:
Curcumin, Chronic Inflammation, Pharmacological EffectsAbstract
Herbal plants Herbal plants in Indonesia have an important role in traditional medicine and public health. The study aims to evaluate the effectiveness and mechanism of action of curcumin in chronic inflammatory therapy. This study employs the Systematic Literature Review (SLR) methodology.. This study uses a database from Scopus of 9 Scopus articles from the range of 2020 to 2025. There are three stages carried out in mapping the effectiveness and mechanism of action of curcumin in chronic inflammatory therapy, namely data harvesting, screening data and Data Analysis and Visualization. The results obtained are that curcumin is effective in chronic inflammatory therapy by inhibiting the main inflammatory pathways (NF-ƙB and JAK/STAT), has antioxidant effects, accelerates tissue regeneration, and functions as an immunomodulator. However, the limited bioavailability of curcumin presents a significant challenge in its application. Nanoformulation technology and its combination with compounds like CMPs can enhance its effectiveness in clinical therapy.The implications of this research are directed to researchers, the community and the government
Downloads
References
Adamczak, A., Ożarowski, M., & Karpiński, T. (2020). Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity. Pharmaceuticals, 13. https://doi.org/10.3390/ph13070153
Afshari, H., Noori, S., Daraei, A., Movahed, M. A., & Zarghi, A. (2023). A novel imidazo[1,2-a]pyridine derivative and its co-administration with curcumin exert anti-inflammatory effects by modulating the STAT3/NF-κB/iNOS/COX-2 signaling pathway in breast and ovarian cancer cell lines. BioImpacts : BI, 14. https://doi.org/10.34172/bi.2023.27618
Aggarwal, S., Ichikawa, H., Takada, Y., Sandur, S., Shishodia, S., & Aggarwal, B. (2006). Curcumin (Diferuloylmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IκBα Kinase and Akt Activation. Molecular Pharmacology, 69, 195–206. https://doi.org/10.1124/MOL.105.017400
Azzini, E., Peña-Corona, S. I., Hernández-Parra, H., Chandran, D., Saleena, L. A. K., Sawikr, Y., Peluso, I., Dhumal, S., Kumar, M., Leyva-Gómez, G., Martorell, M., Sharifi-Rad, J., & Calina, D. (2024). Neuroprotective and anti-inflammatory effects of curcumin in Alzheimer’s disease: Targeting neuroinflammation strategies. Phytotherapy Research, 38(6), 3169–3189. https://doi.org/10.1002/ptr.8200
Buhrmann, C., Mobasheri, A., Busch, F., Aldinger, C., Stahlmann, R., Montaseri, A., & Shakibaei, M. (2011). Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. The Journal of Biological Chemistry, 286 32, 28556–28566. https://doi.org/10.1074/jbc.M111.256180
Butnariu, M., Quispe, C., Koirala, N., Khadka, S., Salgado-Castillo, C. M., Akram, M., Anum, R., Yeskaliyeva, B., Cruz-Martins, N., Kumar, M. M. M., Bagiu, R. V, Razis, A. F. A., Sunusi, U., Kamal, R. M., & Sharifi-Rad, J. (2022). Bioactive Effects of Curcumin in Human Immunodeficiency Virus Infection Along with the Most Effective Isolation Techniques and Type of Nanoformulations. International Journal of Nanomedicine, 17, 3619–3632. https://doi.org/10.2147/IJN.S364501
Camacho-Barquero, L., Villegas, I., Sánchez-Calvo, J., Talero, E., Sánchez-Fidalgo, S., Motilva, V., & De La Lastra, A. (2007). Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis. International Immunopharmacology, 7 3, 333–342. https://doi.org/10.1016/J.INTIMP.2006.11.006
Da Paz Martins, A. S., De Araújo, O. R. P., Da Silva Gomes, A., Araujo, F. L. C., Oliveira, J., De Vasconcelos, J. K. G., Rodrigues, J. I., Cerqueira, I. T., De Freitas Lins Neto, M. Á., Bueno, N., Goulart, M., & Moura, F. (2024). Effect of Curcumin Plus Piperine on Redox Imbalance, Fecal Calprotectin and Cytokine Levels in Inflammatory Bowel Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Pharmaceuticals, 17. https://doi.org/10.3390/ph17070849
Falzone, L., Candido, S., Docea, A., & Calina, D. (2023). Editorial: Inflammation and aging in chronic and degenerative diseases: Current and future therapeutic strategies. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.1122786
Fu, Y.-S., Chen, T.-H., Weng, L., Huang, L., Lai, D., & Weng, C. (2021). Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 141, 111888. https://doi.org/10.1016/j.biopha.2021.111888
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D., Fasano, A., Miller, G., Miller, A., Mantovani, A., Weyand, C., Barzilai, N., Goronzy, J., Rando, T., Effros, R., Lucia, A., Kleinstreuer, N., & Slavich, G. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 25, 1822–1832. https://doi.org/10.1038/s41591-019-0675-0
Hemrajani, C., Negi, P., Parashar, A., Gupta, G., Jha, N. K., Singh, S. K., Chellappan, D. K., & Dua, K. (2022). Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective. Biomedicine and Pharmacotherapy, 147. https://doi.org/10.1016/j.biopha.2022.112633
Heng, W. S., Kruyt, F. A. E., & Cheah, S.-C. (2021). Understanding lung carcinogenesis from a morphostatic perspective: Prevention and therapeutic potential of phytochemicals for targeting cancer stem cells. International Journal of Molecular Sciences, 22(11). https://doi.org/10.3390/ijms22115697
Hosseini, H., Ghavidel, F., Rajabian, A., Homayouni-Tabrizi, M., Majeed, M., & Sahebkar, A. (2024). The Effects of Curcumin Plus Piperine Co-administration on Inflammation and Oxidative Stress: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Current Medicinal Chemistry. https://doi.org/10.2174/0109298673260515240322074849
Hsu, K.-Y., Ho, C.-T., & Pan, M. (2023). The therapeutic potential of curcumin and its related substances in turmeric: From raw material selection to application strategies. Journal of Food and Drug Analysis, 31, 194–211. https://doi.org/10.38212/2224-6614.3454
Ismail, E. N., Zakuan, N., Othman, Z., Vidyadaran, S., Mohammad, H., & Ishak, R. (2025). Polyphenols mitigating inflammatory mechanisms in inflammatory bowel disease (IBD): focus on the NF-ƙB and JAK/STAT pathways. Inflammopharmacology, 33(2), 759–765. https://doi.org/10.1007/s10787-024-01607-8
Jayanto, I., Gunawan, U., & Yaqya, M. (2024). Ethics And Responsibility In Pharmaceutical Practice: Facing Moral Dilemmas In The Modern Era. Journal Of Pharmacopoeia, Pharmacopeia, Vol. 2 No.1, March 2025
Jurenka, J. (2009). Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Alternative Medicine Review : A Journal of Clinical Therapeutic, 14 2, 141–153. https://consensus.app/papers/antiinflammatory-properties-of-curcumin-a-major-jurenka/b8e66f5ef0385385bd63af912ba028ff/
Khansari, N., Shakiba, Y., & Mahmoudi, M. (2009). Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Patents on Inflammation & Allergy Drug Discovery, 3 1, 73–80. https://doi.org/10.2174/187221309787158371
Kocaadam, B., & Sanli̇er, N. (2017). Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical Reviews in Food Science and Nutrition, 57, 2889–2895. https://doi.org/10.1080/10408398.2015.1077195
Kunnumakkara, A., Bordoloi, D., Padmavathi, G., Monisha, J., Roy, N., Prasad, S., & Aggarwal, B. (2017). Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. British Journal of Pharmacology, 174, 1325–1348. https://doi.org/10.1111/bph.13621
Lee, S., Cho, S.-S., Li, Y., Bae, C., Park, K., & Park, D.-H. (2020). Anti-inflammatory Effect of Curcuma longa and Allium hookeri Co-treatment via NF-κB and COX-2 Pathways. Scientific Reports, 10. https://doi.org/10.1038/s41598-020-62749-7
Lee, Y.-M., & Kim, Y.-S. (2024). Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials. Nutrients, 16. https://doi.org/10.3390/nu16111728
Liao, W., Tran, Q. T. N., Peh, H. Y., Chan, C. C. M. Y., & Fred Wong, W. S. (2025). Natural Products for the Management of Asthma and COPD. In Handbook of Experimental Pharmacology (Vol. 287, pp. 175–205). https://doi.org/10.1007/164_2024_709
Liberale, L., Montecucco, F., Tardif, J., Libby, P., & Camici, G. (2020). Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease. European Heart Journal. https://doi.org/10.1093/eurheartj/ehz961
Manabe, I. (2011). Chronic inflammation links cardiovascular, metabolic and renal diseases. Circulation Journal : Official Journal of the Japanese Circulation Society, 75 12, 2739–2748. https://doi.org/10.1253/CIRCJ.CJ-11-1184
Mancillas-Quiroz, J. A., Carrasco-Portugal, M., Mondragón-Vásquez, K., Huerta-Cruz, J., Rodríguez-Silverio, J., Rodríguez-Vera, L., Reyes-García, J. G., Flores-Murrieta, F., Domínguez-Chávez, J., & Rocha-González, H. (2024). Development of a Novel Co-Amorphous Curcumin and L-Arginine (1:2): Structural Characterization, Biological Activity and Pharmacokinetics. Pharmaceutics, 17. https://doi.org/10.3390/pharmaceutics17010011
Megha, K., Joseph, X., Akhil, V., & Mohanan, P. (2021). Cascade of immune mechanism and consequences of inflammatory disorders. Phytomedicine, 91, 153712. https://doi.org/10.1016/j.phymed.2021.153712
Memarzia, A., Khazdair, M., Behrouz, S., Gholamnezhad, Z., Jafarnezhad, M., Saadat, S., & Boskabady, M. (2021). Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive review. BioFactors, 47, 311–350. https://doi.org/10.1002/biof.1716
Menon, V., & Sudheer, A. (2007). Antioxidant and anti-inflammatory properties of curcumin. Advances in Experimental Medicine and Biology, 595, 105–125. https://doi.org/10.1007/978-0-387-46401-5_3
Mustofa, D. A. S., Sahari, F. D., Pramudani, S. A., Hidayah, A. B., Tsany, S. F., & Salasia, S. I. O. (2024). Combination of curcuminoid and collagen marine peptides for healing diabetic wounds infected by methicillin-resistant Staphylococcus aureus. Veterinary World, 17(4), 933–939. https://doi.org/10.14202/vetworld.2024.933-939
Newton, K., & Dixit, V. (2012). Signaling in innate immunity and inflammation. Cold Spring Harbor Perspectives in Biology, 4 3. https://doi.org/10.1101/cshperspect.a006049
Oladimeji, O., Cross, J., & Keathley-Herring, H. (2020). System dynamics applications in performance measurement research: progress and challenges. Management Decision. https://doi.org/10.1108/md-11-2019-1596
Patel, S., Acharya, A., Ray, R., Agrawal, R., Raghuwanshi, R., & Jain, P. (2020). Cellular and molecular mechanisms of curcumin in prevention and treatment of disease. Critical Reviews in Food Science and Nutrition, 60, 887–939. https://doi.org/10.1080/10408398.2018.1552244
Paulino, N., Paulino, A., Diniz, S., De Mendonça, S., Gonçalves, I., Flores, F. F., Santos, R., Rodrigues, C., Pardi, P., & Suarez, J. A. Q. (2016). Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways. Bioorganic & Medicinal Chemistry, 24 8, 1927–1935. https://doi.org/10.1016/j.bmc.2016.03.024
Pourhabibi-Zarandi, F., Rafraf, M., Zayeni, H., Asghari-Jafarabadi, M., & Ebrahimi, A.-A. (2024). The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial. Phytotherapy Research : PTR. https://doi.org/10.1002/ptr.8225
Prasad, S., Gupta, S., Tyagi, A., & Aggarwal, B. (2014). Curcumin, a component of golden spice: from bedside to bench and back. Biotechnology Advances, 32 6, 1053–1064. https://doi.org/10.1016/j.biotechadv.2014.04.004
Prasad, S., Sung, B., & Aggarwal, B. (2012). Age-associated chronic diseases require age-old medicine: role of chronic inflammation. Preventive Medicine, 54 Suppl. https://doi.org/10.1016/j.ypmed.2011.11.011
Sharma, R., Gescher, A., & Steward, W. (2005). Curcumin: the story so far. European Journal of Cancer, 41 13, 1955–1968. https://doi.org/10.1016/J.EJCA.2005.05.009
Turner, M., Nedjai, B., Hurst, T., & Pennington, D. (2014). Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Biochimica et Biophysica Acta, 1843 11, 2563–2582. https://doi.org/10.1016/j.bbamcr.2014.05.014
Wardani, R. S., Schellack, N., Govender, T., Dhulap, A. N., Utami, P., Malve, V., & Wong, Y. C. (2023). Treatment of the common cold with herbs used in Ayurveda and Jamu: monograph review and the science of ginger, liquorice, turmeric and peppermint. Drugs in Context, 12. https://doi.org/10.7573/dic.2023-2-12
Winata, N., Hasyim, D. M., & Primulyanto, B. A. (2024). Pharmaceutical Involvement In Infectious Disease Control: Strategies, Challenges, And Solutions. Pharmacopeia, Vol. 2 No.1, March 2025
Wong, P.-F., Dharmani, M., & Ramasamy, T. S. (2023). Senotherapeutics for mesenchymal stem cell senescence and rejuvenation. Drug Discovery Today, 28(1). https://doi.org/10.1016/j.drudis.2022.103424
Xu, X.-Y., Meng, X., Li, S., Gan, R., Li, Y., & Li, H. (2018). Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives. Nutrients, 10. https://doi.org/10.3390/nu10101553
Yang, H., Zhang, H., Tian, L., Guo, P., Liu, S., Chen, H., & Sun, L. (2024). Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway. Lupus Science & Medicine, 11. https://doi.org/10.1136/lupus-2024-001220
Yu, Y., Shen, Q., Lai, Y., Park, S. Y., Ou, X., Lin, D., Jin, M., & Zhang, W. (2018). Anti-inflammatory Effects of Curcumin in Microglial Cells. Frontiers in Pharmacology, 9. https://doi.org/10.3389/fphar.2018.00386
Zhang, X., Zhang, H., Wang, J., Chen, Y., Lin, J., Wang, Q., Wu, C., Chen, H., & Lin, Y. (2025). Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF-κB signaling pathway. BioFactors, 51 1. https://doi.org/10.1002/biof.70001
Downloads
Additional Files
Published
Issue
Section
License
Copyright (c) 2025 Muntasir Muntasir, Anggia Faradina, Tutik Wuryandari, Khrisna Agung Cendekiawan (Author)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
