The Effect of Black Garlic Extract as a Curative Therapy on Increased Total Cholesterol in Obesity Model Rats
DOI:
https://doi.org/10.62872/16njj366Keywords:
black garlic, total cholesterol, obesityAbstract
Obesity is a condition of excess body fat accumulation that often triggers an increase in total cholesterol levels in the blood, thereby increasing the risk of cardiovascular disease. Black garlic, a fermented garlic product, is known to contain bioactive compounds such as S-allylcysteine (SAC) which is effective in lowering cholesterol levels. Objective: To determine the effect of black garlic extract as a preventive therapy in obesity model rats induced by a high-fat and fructose diet. Method: The research method used an experimental design with a pre- and post-test group design approach. A total of 28 male Sprague Dawley rats were divided into four groups: negative control (standard diet AIN 93), positive control (high-fat and fructose diet), and two treatment groups each given black garlic extract at a dose of 1.6 ml/day and 0.8 ml/day. Total cholesterol levels were measured before and after the intervention using the spectrophotometric method. Data analysis used SPSS with the Independent t-test. Results: The results showed that administration of black garlic extract significantly reduced total cholesterol levels in the treatment group compared to the positive control group. A dose of 1.6 ml/day produced a greater cholesterol-lowering effect than a dose of 0.8 ml/day. Conclusion: Black garlic extract was effective in lowering total cholesterol levels in an obese rat model.
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References
Indonesian Health Research and Development Agency. (2019). West Sumatra Province RISKESDAS 2018 Report. In National Riskesdas Report 2018.
Chae, J., Lee, E., Min, S., Won, H., Kim, S., & Nam, J. (2023a). Biomedicine & Pharmacotherapy Aged black garlic (Allium sativum L.) and aged black elephant garlic (Allium ampeloprasum L.) alleviate obesity and attenuate obesity-induced muscle atrophy in diet-induced obese C57BL/6 mice. 163(March).
Chae, J., Lee, E., Min, S., Won, H., Kim, S., & Nam, J. (2023b). Biomedicine & Pharmacotherapy Aged black garlic (Allium sativum L.) and aged black elephant garlic (Allium ampeloprasum L.) alleviate obesity and attenuate obesity-induced muscle atrophy in diet-induced obese C57BL/6 mice. Biomedicine & Pharmacotherapy, 163(May), 114810. https://doi.org/10.1016/j.biopha.2023.114810
Ha, A. W., Ying, T., & Kim, W. K. (2015). The effects of black garlic (Allium satvium) extracts on lipid metabolism in rats fed a high fat diet. 9(1), 30–36. https://doi.org/10.4162/nrp.2015.9.1.30
Hales, C. M., Carroll, M. D., Fryar, C. D., & Ogden, C. L. (2020). Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017-2018. NCHS Data Briefs, 360, 1–8.
Henning, R. J. (2021). Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity. American Journal of Cardiovascular Disease, 11(4), 504–529. http://www.ncbi.nlm.nih.gov/pubmed/34548951%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC8449192
Jebari-Benslaiman, S., Galicia-García, U., Larrea-Sebal, A., Olaetxea, J.R., Alloza, I., Vandenbroeck, K., Benito-Vicente, A., & Martín, C. (2022). Pathophysiology of Atherosclerosis. International Journal of Molecular Sciences, 23(6), 1–38. https://doi.org/10.3390/ijms23063346
Kawai, T., Autieri, M.V., & Scalia, R. (2021). Adipose tissue inflammation and metabolic dysfunction in obesity. American Journal of Physiology - Cell Physiology, 320(3), C375–C391. https://doi.org/10.1152/ajpcell.00379.2020
Kimura, S., Tung, Y., Pan, M., Su, N., Lai, Y., & Cheng, K. (2017). Black garlic : A critical review of its production, bioactivity, and application ScienceDirect Black garlic : A critical review of its production, bioactivity, and application. 25(1).
Samir Softic, Cohen, D. E., & Kahn, R. (2017). Role of Dietary Fructose and Hepatic de novo Lipogenesis in Fatty Liver Disease. 61(5), 1282–1293. https://doi.org/10.1007/s10620-016-4054-0.Role
Susanti, N., Rahmawati, E., & K, RA (2019). Effect of High Fructose Diet on Lipid Profile of Wistar Rats Rattus norvegicus. 3(2), 26–35..
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Copyright (c) 2026 Shalsa Nabilla, Prima Adelin, Berri Ramadhoni, Letvimona, Rahma Triyana (Author)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
