Impact of Sleep Quality on The Immune System in Adult Individuals

Authors

  • Erika Erika Sekolah Tinggi Ilmu Kesehatan Mitra Husada Medan Author
  • Olyvia Rosalia Universitas Islam Negeri Sulthan Thaha Saifuddin Jambi Author

DOI:

https://doi.org/10.62872/6tm8g921

Keywords:

sleep quality, immune system, inflammatory cytokines, infection, stress

Abstract

This study aims to explore the relationship between sleep quality and the immune system in adults. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI), while immune function was evaluated through levels of inflammatory cytokines (such as IL-6 and CRP) and the frequency of infections in the past three months. The results showed that the majority of respondents had poor to moderate sleep quality, which was associated with increased levels of proinflammatory cytokines and a higher frequency of infections. A decline in sleep quality was significantly correlated with a decrease in immune resistance, indicating that poor sleep can disrupt the body's defense mechanisms. Psychosocial factors such as stress were also found to worsen both sleep quality and immune function. These findings highlight the importance of sleep quality in maintaining a healthy immune system, with implications for the development of lifestyle-based interventions to improve sleep quality and immune resilience. This study opens opportunities for further in-depth research on the causal mechanisms between sleep and immunity.

Downloads

Download data is not yet available.

References

Abd El-Kader, S. M., & Al-Jiffri, O. H. (2020). Aerobic exercise affects sleep, psychological wellbeing and immune system parameters among subjects with chronic primary insomnia. African health sciences, 20(4), 1761-9.

Al Meslamani, A. Z. (2024). How does sleep influence asthma through immunity?. Expert Review of Clinical Immunology, 20(4), 323-326.

Almondes, K. M. D., Marín Agudelo, H. A., & Jiménez-Correa, U. (2021). Impact of sleep deprivation on emotional regulation and the immune system of healthcare workers as a risk factor for COVID 19: Practical recommendations from a task force of the Latin American Association of sleep psychology. Frontiers in psychology, 12, 564227.

Besedovsky, L., Lange, T., & Haack, M. (2019). The sleep-immune crosstalk in health and disease. Physiological reviews.

Bocek, J., Prasko, J., Genzor, S., Hodny, F., Vanek, J., Pobeha, P., ... & Ociskova, M. (2023). Sleep disturbance and immunological consequences of COVID-19. Patient preference and adherence, 667-677.

Bongiorno, C., Moscatiello, S., Baldari, M., Saudelli, E., Zucchini, S., Maltoni, G., ... & Di Dalmazi, G. (2023). Sleep quality and sex-related factors in adult patients with immune-mediated diabetes: a large cross-sectional study. Acta Diabetologica, 60(5), 663-672.

Bryant, P. A., Trinder, J., & Curtis, N. (2004). Sick and tired: does sleep have a vital role in the immune system?. Nature Reviews Immunology, 4(6), 457-467.

Feuth, T. (2024). Interactions between sleep, inflammation, immunity and infections: a narrative review. Immunity, Inflammation and Disease, 12(10), e70046.

Grochowalska, K., Ziętkiewicz, M., Więsik-Szewczyk, E., Matyja-Bednarczyk, A., Napiorkowska-Baran, K., Nowicka-Sauer, K., ... & Zdrojewski, Z. (2023). Subjective sleep quality and fatigue assessment in Polish adult patients with primary immunodeficiencies: A pilot study. Frontiers in Immunology, 13, 1028890.

Irwin, M. R. (2019). Sleep and inflammation: partners in sickness and in health. Nature Reviews Immunology, 19(11), 702-715.

Jin, R. R., Cheung, C. N. M., Wong, C. H., Lo, C. C., Lee, C. P., Tsang, H. W., ... & Lee, T. M. (2023). Sleep quality mediates the relationship between systemic inflammation and neurocognitive performance. Brain, Behavior, & Immunity-Health, 30, 100634.

Kow, C. S., & Hasan, S. S. (2021). Do sleep quality and sleep duration before or after COVID-19 vaccination affect antibody response?. Chronobiology International, 38(7), 941-943.

Lueke, N. A., & Assar, A. (2024). Poor sleep quality and reduced immune function among college students: Perceived stress and depression as mediators. Journal of american college HealtH, 72(4), 1112-1119.

Piber, D., Cho, J. H., Lee, O., Lamkin, D. M., Olmstead, R., & Irwin, M. R. (2022). Sleep disturbance and activation of cellular and transcriptional mechanisms of inflammation in older adults. Brain, Behavior, and Immunity, 106, 67-75.

Singh, K. K., Ghosh, S., Bhola, A., Verma, P., Amist, A. D., Sharma, H., ... & Sinha, J. K. (2024). Sleep and Immune System Crosstalk: Implications for Inflammatory Homeostasis and Disease Pathogenesis. Annals of Neurosciences, 09727531241275347.

Sowers, K. L., Sawaged, A., & Bowen, B. (2023). Perceived Sleep Quality in individuals with inborn errors of immunity. Journal of Clinical Immunology, 43(6), 1221-1228.

Sweatt, S. K., Gower, B. A., Chieh, A. Y., Liu, Y., & Li, L. (2018). Sleep quality is differentially related to adiposity in adults. Psychoneuroendocrinology, 98, 46-51.

Tan, H. L., Kheirandish-Gozal, L., & Gozal, D. (2019). Sleep, sleep disorders, and immune function. Allergy and sleep: basic principles and clinical practice, 3-15.

Walsh, N. P., Kashi, D. S., Edwards, J. P., Richmond, C., Oliver, S. J., Roberts, R., ... & Greeves, J. P. (2023). Good perceived sleep quality protects against the raised risk of respiratory infection during sleep restriction in young adults. Sleep, 46(1), zsac222.

Żerek, M., & Sitarek, G. (2024). Sleep Quality and Immune Function: Implications for Overall Health–A Literature Review. Journal of Education, Health and Sport, 75, 56048-56048.

Downloads

Published

2025-04-30

How to Cite

Impact of Sleep Quality on The Immune System in Adult Individuals. (2025). Oshada, 2(2), 142-150. https://doi.org/10.62872/6tm8g921

Similar Articles

11-20 of 65

You may also start an advanced similarity search for this article.