Adherence Trends in the Use of Innovative Drugs for Diabetes: Evaluation of Their Effectiveness and Safety
DOI:
https://doi.org/10.62872/7474ys44Keywords:
Medication Compliance, Innovative Diabetes Therapy, Evaluation of Effectiveness and SafetyAbstract
Type 2 diabetes mellitus continues to show increasing global and national prevalence, driving the need for more effective and personalized management approaches. Innovative therapies such as SGLT2 inhibitors and GLP1 receptor agonists present as pharmacological solutions with promising cardiovascular and renoprotective benefits. However, the effectiveness of these therapies in clinical practice is determined not only by drug efficacy, but also by patient adherence and health system readiness. This study used a qualitative approach based on literature review to evaluate the challenges of adherence as well as the effectiveness and safety of innovative therapies in type 2 diabetes. The results of the analysis showed that although innovative drugs have been proven effective in clinical studies, response variability and side effects in real practice require realworld evidence (RWE)based monitoring. Obstacles such as high costs, unequal access, and low patient understanding are major barriers to widespread implementation of therapy. Adherenceenhancing strategies, technologybased education, and inclusive financing policies are needed to optimize the benefits of therapy. Thus, successful diabetes management through innovative therapies requires an integration of scientific approaches, public policies, and active patient participation in a fair and responsive health care system.
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Ahmed, M., Saeed, A., Khan, M. Z., Javaid, S. Z., Aslam, F., & Dar, S. I. (2023). A Comparison Of The Effects Of Empagliflozin And Sitagliptin, When Combined With Metformin, On Lipid Levels In Patients With Type 2 Diabetes: A Clinical Investigation. Cureus, 15(9).
Arini, M. (2021). Waktu Kontak Petugas Dengan Pasien Terhadap Kualitas Layanan: Studi Perspektif Petugas Kesehatan Di Puskesmas X: Health Workers’contacts Time With Patients Against Quality Of Service: A Perspective Study On Health Officers At X Community Health Center. Quality: Jurnal Kesehatan, 15(2), 8494.
Besmaya, B. M., & Laksono, S. (2023). Mekanisme Penghambat Sodiumglukosa Transport Protein2 (SGLT2i) Pada Penyakit Kardiovaskular: Sebuah Tinjauan. MPI (Media Pharmaceutica Indonesiana), 5(1), 7185.
Fajriyah, N., Trisnawati, I., & Samudera, W. S. (2020). Program Pendidikan Dan Dampak Aktivitas Fisik Pada Penanda Biokimia Pasien Diabetes Mellitus Tipe 2: A Systematic Review. Jurnal Penelitian Kesehatan" SUARA FORIKES"(Journal Of Health Research" Forikes Voice"), 11(3), 237244.
Faridha Alfiatur Rohmaniah, F. (2022). Pengaruh Edukasi Kesehatan Terstruktur Pendekatan Health Belief Model Terhadap Efikaksi Diri Dalam Kepatuhan Menjalani Hemodialisa (Doctoral Dissertation, Universitas Karya Husada).
Farisya, M. R., Purnomo, S., & Septiawan, T. (2024). Hubungan Tingkat Pengetahuan Dengan Kepatuhan Minum Obat Pada Penderita Hipertensi. Jurnal Keperawatan Florence Nightingale, 7(2), 321331.
Ferliani, H. S., Koesnoe, S., & Shatri, H. (2015). Kepatuhan Berobat Pada Pasien Asma Tidak Terkontrol Dan Faktorfaktor Yang Berhubungan. Jurnal Penyakit Dalam Indonesia| Vol, 2(3).
Firmansyah, Y., & Widjaja, G. (2022). Pemberlakuan Clinical Pathway Dalam Pemberian Layanan Kesehatan Dan Akibat Hukumnya. Crossborder, 5(1), 536573.
Godfrey, S., Barnes, A., Gao, J., Sulistio, M. S., Katz, J. N., & Chuzi, S. (2024). Shared Decisionmaking In Palliative And Endoflife Care In The Cardiac Intensive Care Unit. US Cardiology Review, 18, E13.
Hanggoro, I. W. (2025). Peran Komunikasi Efektif Antara Dokter Dan Pasien. Jurnal Inovasi Kesehatan Adaptif, 7(1).
Hanson, K., Brikci, N., Erlangga, D., Alebachew, A., De Allegri, M., Balabanova, D., ... & Wurie, H. (2022). The Lancet Global Health Commission On Financing Primary Health Care: Putting People At The Centre. The Lancet Global Health, 10(5), E715e772.
He, J., Morales, D. R., & Guthrie, B. (2020). Exclusion Rates In Randomized Controlled Trials Of Treatments For Physical Conditions: A Systematic Review. Trials, 21, 111.
Hijriyati, Y., Wulandari, N. A., & Sutandi, A. (2023). Analisis Deskriptif: Usia Dan Tingkat Kepatuhan Minum Obat Pasien Diabetes Mellitus Tipe 2. Binawan Student Journal, 5(2), 15.
Ikawati, R., Pramudiana, I. D., Widyawati, W., & Roekminiati, S. (2025). Peran Inovasi (PETIK DUREN) Pelayanan Tilik Kampung Penduduk Rentan Dalam Meningkatkan Kesejahteraan Masyarakat Kabupaten Lamongan. JURNAL PENDIDIKAN DAN ILMU SOSIAL (JUPENDIS), 3(1), 284300.
Kohsaka, S., Lam, C. S., Kim, D. J., Cavender, M. A., Norhammar, A., Jørgensen, M. E., ... & Magliano, D. (2020). Risk Of Cardiovascular Events And Death Associated With Initiation Of SGLT2 Inhibitors Compared With DPP4 Inhibitors: An Analysis From The CVDREAL 2 Multinational Cohort Study. The Lancet Diabetes & Endocrinology, 8(7), 606615.
Kruk, M. E., Gage, A. D., Arsenault, C., Jordan, K., Leslie, H. H., Roderdewan, S., ... & Pate, M. (2018). Highquality Health Systems In The Sustainable Development Goals Era: Time For A Revolution. The Lancet Global Health, 6(11), E1196e1252.
Lapui, M. (2021). Efektifitas Pengembangan Aplikasi Edukasi Surveilans Deteksi Dini Kusta (SIDINI) Di Wilayah Puskesmas Ampana Barat Kabupaten Tojo Una Una Provinsi Sulawesi Tengah= Effectiveness Of Leprosy Early Detection Education And Surveillance Applications Development (Sidini) In West Ampana Health Center Area Tojo Una Una Regency Central Sulawesi Province (Doctoral Dissertation, Universitas Hasanuddin).
Lioncu, N., KM, M., & Mamlukah, S. K. M. (2023). Eleaflet Untuk Meningkatkan Kepatuhan Pengobatan Penderita Hipertensi. CV. Mitra Edukasi Negeri.
Matthews, D. R., Li, Q., Perkovic, V., Mahaffey, K. W., De Zeeuw, D., Fulcher, G., ... & Neal, B. (2019). Effects Of Canagliflozin On Amputation Risk In Type 2 Diabetes: The CANVAS Program. Diabetologia, 62, 926938.
Mayer, G. J., Wanner, C., Weir, M. R., Inzucchi, S. E., Koitkaweber, A., Hantel, S., ... & Cherney, D. Z. (2019). Analysis From The EMPAREG OUTCOME® Trial Indicates Empagliflozin May Assist In Preventing The Progression Of Chronic Kidney Disease In Patients With Type 2 Diabetes Irrespective Of Medications That Alter Intrarenal Hemodynamics. Kidney International, 96(2), 489504.
Mufid, S. N., & DR, T. P. I. M. O. C. R. (2018). Gambaran Tatalaksana Nyeri Skala 13 Oleh Perawat Pada Pasien Kanker Di Ruang Perawatan Onkologi Rsup Dr. Kariadi Semarang. Jurnal Ilmu Keperawatan Dan Kebidanan (JIKK), 3(4), 197254.
Mulyana, A., Vidiati, C., Danarahmanto, P. A., Agussalim, A., Apriani, W., Fiansi, F., ... & Martono, S. M. (2024). Metode Penelitian Kualitatif. Penerbit Widina.
Paramitha, A. A. P., Wikananda, G. D. D., & Lestari, D. N. D. (2022). Efek Glucagonlike Peptide1 Terhadap Kejadian Penyakit Kardiovaskular Dan Ginjal Pada Pasien Diabetes Melitus Tipe 2. Intisari Sains Medis, 13(3), 843850.
Prasetya, D., Layyinah, A., Putri, S., Rosita, E., Nurjanah, A. I., & Maftuchan, A. (2023). Konsekuensi Finansial Pengobatan Kanker Di Indonesia: Studi Kasus Penderita Kanker Di Ibu Kota Jakarta. Perkumpulan PRAKARSA.
Pratiwi, L., KM, M., Anggraini, D. D., Keb, S. S. T., & Hapsari, E. (2024). Diabetes Mellitus Dan Gestational Diabetes Mellitus. CV Jejak (Jejak Publisher).
Rahma, C. A., Oktarlina, R. Z., Aditya, M. A. M., & Berawi, K. N. (2024). Literature Review: Rationality Of Oral Antidiabetic Drug Administration In Type 2 Diabetes Mellitus Patients. Medical Profession Journal Of Lampung, 14(9), 17561761.
Ridho, M. N., Astuti, R. D. I., & Dharmmika, S. (2025, February). Karakteristik Penderita Diabetes Mellitus Tipe 2 Yang Dirawat Inap Di RSUD Alihsan Tahun 2024. In Bandung Conference Series: Medical Science (Vol. 5, No. 1, Pp. 12211230).
Rumintjap, F. M., Wahyudi, A., Meher, C., Yuliana, D., & Yuwanto, L. (2024). Patient Experience: Innovating The Application Of LAFKI Concept In Personcentred Care At Healthcare Facilities. FJST, 3(4), 64170.
Saibi, Y., Romadhon, R., & Nasir, N. M. (2020). Kepatuhan Terhadap Pengobatan Pasien Diabetes Melitus Tipe 2 Di Puskesmas Jakarta Timur. Jurnal Farmasi Galenika (Galenika Journal Of Pharmacy)(Ejournal), 6(1), 94103.
Ulhaq, D. D. (2022). Analisis Efektivitas Biaya Terapi Kombinasi Insulin Dengan Obat Antidiabetes Oral Pada Pasien Rawat Jalan Penderita Diabetes Melitus Tipe 2 Di RSUD Dr. Soehadi Prijonegoro Sragen (Doctoral Dissertation, Universitas Islam Negeri Maulana Malik Ibrahim).
Wahyuningrum, R., Wahyono, D., Mustofa, M., & Prabandari, Y. S. (2020). Masalahmasalah Terkait Pengobatan Diabetes Melitus Tipe 2: Sebuah Studi Kualitatif. Indonesian Journal Of Clinical Pharmacy, 9(1), 26.
Yusi, A., Prih, S., Siti, A., & Jenny, P. (2019). Analisis Trend Harga Obat Sebelum Dan Sesudah Penerapan Ecatalogue Di Rumah Sakit. JMPF, 9(1), 111..
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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
