Risk Factors for Breast Cancer at Undata Regional General Hospital, Central Sulawesi Province
DOI:
https://doi.org/10.62872/9vrfh392Keywords:
Risk Factors, Breast Cancer, Menarche, Family History, Hormonal Contraception, Age At ChildbirthAbstract
Breast cancer is one of the most common cancers among women and a growing public health problem, including at Undata Regional General Hospital, Central Sulawesi, where inpatient cases rose from 38 in 2022 to 144 by September 2025. This study aimed to analyze the risk factors associated with breast cancer at Undata Hospital. This is a quantitative study with a case-control design involving 104 respondents (52 cases and 52 controls) selected through purposive sampling. The variables were studied menarche, family history, lactation history, hormonal contraceptive use, and age at first childbirth. Data were analyzed using the Odds Ratio (OR) test in bivariate analysis and multiple logistic regression in multivariate analysis. The results showed that all variables were significantly associated with breast cancer after adjustment: early menarche <12 years (AOR=8.942; 95% CI=1.963–40.740), family history (AOR=13.753; 95% CI=2.973–63.629), lactation duration <12 months (AOR=14.024; 95% CI=4.010–49.045), hormonal contraceptive use ≥5 years (AOR=3.226; 95% CI=1.035–10.060), and age at first childbirth ≥30 years (AOR=9.830; 95% CI=1.703–56.745). The most dominant factor was a lactation duration of less than 12 months. Breast cancer incidence is influenced by an interrelated combination of hormonal, reproductive, and genetic factors, highlighting the need for stronger health promotion, risk-factor education, hormonal contraceptive counseling, and early-detection programs.
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References
Agussalim, N. Q. (2024). Analisis Self Efficacy sebagai Faktor Penentu Aktifitas Fisik pada Pasien Kanker Payudara.
American Cancer Society. (2024). Breast Cancer Facts & Figures 2024-2025.
Ang, B. H., Teo, S. H., & Ho, W. K. (2024). Systematic review and meta-analysis of lifestyle and reproductive factors associated with risk of breast cancer in Asian women. Cancer Epidemiology Biomarkers and Prevention, 33(10), 1273–1285. https://doi.org/10.1158/1055-9965.EPI-24-0005
Armini, N. W., Somoyani, N. K., & Mahayati, N. M. D. (2024). The impact of breastfeeding duration on breast cancer risk: A systematic review. Ejournal Poltekkes Kemenkes Denpasar, 2, 452–467.
Aulia, R. (2025). Hubungan tingkat pengetahuan dengan sikap pemeriksaan SADARI pada remaja putri SMAN 7 Makassar. 2(1), 17–30.
Badan Penelitian dan Pengembangan Kesehatan. (2018). Laporan Nasional Riskesdas 2018.
Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 74(3), 229–263. https://doi.org/10.3322/caac.21834
Christopher, E., Dee, C., Eala, M. A., Laversanne, M., Ginsburg, O., Gomez, S. L., Jay, E., Feliciano, G., Ng, K., Matsuda, T., Sangrajrang, S., Pathy, N. B., Suzanna, E., Bui, D., Wei, W.-Q., Won, Y.-J., Foo, L. L., Ling, A., Mery, L., … Nam, V. (2025). Cancer in Southeast Asia: A comparative analysis of 2022 incidence and mortality data.
Denny, P., Gatsu, A., & Cahyani, A. A. E. (2022). Hubungan faktor risiko usia dengan angka kejadian kanker payudara dan tumor jinak payudara di RSUD Wangaya Kota Denpasar tahun 2019–2022. 434–441.
Firman, N. (2022). Fakumi Medical Journal. 2(5), 288–296.
Fitzpatrick, D., Pirie, K., Reeves, G., Green, J., & Beral, V. (2023). Combined and progestagen-only hormonal contraceptives and breast cancer risk: A UK nested case–control study and meta-analysis. PLoS Medicine, 20(3). https://doi.org/10.1371/journal.pmed.1004188
Fu, M., Peng, Z., Wu, M., Lv, D., Li, Y., & Lyu, S. (2025). Current and future burden of breast cancer in Asia: A GLOBOCAN data analysis for 2022 and 2050. Breast, 79. https://doi.org/10.1016/j.breast.2024.103835
Hassan, F. M. (2025). Risk factors associated with breast cancer among women in Iraq: A case-control study. Asian Pacific Journal of Cancer Prevention, 26(5), 1701–1708. https://doi.org/10.31557/APJCP.2025.26.5.1701
Herita, S. I. (2024). Hubungan lama periode menyusui dengan kejadian kanker payudara pada wanita multipara di RSUD Dr. H. Abdul Moeloek Provinsi Lampung tahun 2022. 10(23), 753–760.
Hero, S. K. (2021). Faktor risiko kanker payudara. Jurnal Medika Hutama, 3(1), 1533–1538.
Kemenkes RI. (2018). Keputusan Menteri Kesehatan Republik Indonesia tentang Pedoman Nasional Pelayanan Kedokteran Tatalaksana Kanker Payudara.
Kemenkes RI. (2024). Rencana Kanker Nasional 2024–2034: Strategi Indonesia dalam Upaya Melawan Kanker. Kementerian Kesehatan Republik Indonesia.
Khuzaiyah, S. (2024). Menarche dan pubertas dini: Kajian terbaru tentang penyebab pubertas dini serta dampaknya terhadap kesehatan perempuan. September, 205–218.
Lei, S., Zheng, R., Zhang, S., Wang, S., Chen, R., Sun, K., Zeng, H., Zhou, J., & Wei, W. (2021). Global patterns of breast cancer incidence and mortality: A population-based cancer registry data analysis from 2000 to 2020. Cancer Communications, 41(11), 1183–1194. https://doi.org/10.1002/cac2.12207
Li, J., Pandian, V., Davidson, P. M., Song, Y., Chen, N., & Fong, D. Y. T. (2025). Burden and attributable risk factors of non-communicable diseases and subtypes in 204 countries and territories, 1990–2021: A systematic analysis for the global burden of disease study 2021. International Journal of Surgery, 111(3), 2385–2397. https://doi.org/10.1097/JS9.0000000000002260
Li, N., Deng, Y., Zhou, L., Tian, T., Yang, S., Wu, Y., Zheng, Y., Zhai, Z., Hao, Q., Song, D., Zhang, D., Kang, H., & Dai, Z. (2019). Global burden of breast cancer and attributable risk factors in 195 countries and territories, from 1990 to 2017: Results from the Global Burden of Disease Study 2017. Journal of Hematology and Oncology, 12(1). https://doi.org/10.1186/s13045-019-0828-0
Lubis, A. M. (2023). Faktor yang mempengaruhi usia menarche di negara berkembang dan negara maju.
Marlia, T. (2024). Hubungan antara usia menarche dan riwayat penggunaan alat kontrasepsi dengan menopause dini pada lansia di Desa Dukuh Indramayu. 6(2), 94–102.
Marlita, F. (2025). Hubungan peran suami dengan pemberian ASI pada ibu nifas di Klinik Bidan Ria Yulisa Kabupaten Bogor tahun 2024.
Meylissa, & Lestari, D. (2024). Hubungan usia melahirkan anak pertama dengan kejadian kanker payudara di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh. Medic Nutricia: Jurnal Ilmu Kesehatan, 4(3).
Ningrum, M. P. (2021). Determinan kejadian kanker payudara pada wanita usia subur (15–49 tahun). 1(3), 362–370.
Obeagu, E. I. P. (2024). Exploring the profound link: Breastfeeding's impact on alleviating the burden of breast cancer – A review. 103(15).
Prazeris. (2023). Gambaran sikap wanita usia subur tentang deteksi dini kanker serviks dengan metode IVA di Puskesmas Umbulharjo 1 tahun 2024. 1–29.
Pringsewu, Agnessia, M., & Sary, L. (2023). Faktor risiko yang berhubungan dengan kanker payudara. 9, 14–21.
Qhotrunnada. (2023). Hubungan usia menarche dan paritas dengan kejadian kanker payudara di Ruang Bedah Onkologi RSUD Jenderal Ahmad Yani. 5–25.
Rahmatia, S. (2024). Fakumi Medical Journal. 04(06), 473–484.
Sayon-Orea, C., Romanos-Nanclares, A., Bullón-Vela, V., Chiva-San Roman, I., Caiado, B., Ondarra-Erdozain, M., Delgado-Rodriguez, M., & Martínez-González, M. A. (2025). Effect of duration of hormonal contraceptive use on breast cancer risk: A systematic review and meta-analysis of cohort studies. Maturitas, 202. https://doi.org/10.1016/j.maturitas.2025.108750
Suanjaya, M. A., Setyobudi, I., & Santosa, H. (2025). Hubungan obesitas, usia, dan riwayat kanker payudara dalam keluarga dengan kejadian kanker payudara di RSUD Provinsi NTB. 13(1), 408–418.
Sugiarto. (2024). Analisis hubungan ekspresi gen HIF-1, VEGF, kadar Ki67 dan gambaran histopatologi jaringan payudara mencit BALB/C yang diinduksi DMBA dan AntiVEGF.
Sukma. (2022). Model SUKMA berbasis web sebagai upaya pencegahan primer kanker payudara pada wanita usia subur di Kota Padang.
Sukmayenti, & Sari, N. (2018). Hubungan faktor reproduksi dengan kejadian kanker payudara pada wanita di RSUP Dr. M. Djamil Padang. Jurnal Riset Hesti Medan, 3(2), 58–63.
Sulaeman, R. (2021). Riwayat penggunaan kontrasepsi hormonal pada penderita kanker payudara (Vol. 3, Issue 1). http://jkt.poltekkes-mataram.ac.id/index.php/home/index
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660
Wandari, I. S. (2025). Hubungan usia, penggunaan kontrasepsi hormonal, dan riwayat menyusui dengan kejadian kanker payudara di RSUD Provinsi NTB. 02(02), 36–44.
Wang, H., MacInnis, R. J., & Li, S. (2023). Family history and breast cancer risk for Asian women: A systematic review and meta-analysis. BMC Medicine, 21(1). https://doi.org/10.1186/s12916-023-02950-3
Yolanda, A. T. I. A. (2023). Determinan perilaku pemeriksaan payudara sendiri (SADARI) pada mahasiswi Fakultas Kesehatan Masyarakat Universitas Indonesia tahun 2022. 3(1). https://doi.org/10.7454/bikfokes.v3i1.1034
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Copyright (c) 2026 Andi Zuhra Ibrahim, Rajindra Rajindra, Zhanaz Tasya (Author)
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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
