DEMENTIA
DOI:
https://doi.org/10.62872/2k2n2s87Keywords:
Dementia, Alzheimer's, Neuropsychological Diagnosis, Cognitive Function, Dementia TherapyAbstract
Dementia is a progressive neurodegenerative syndrome characterized by cognitive decline that significantly impairs daily activities and individual independence. This article aims to comprehensively review the clinical aspects of dementia, including epidemiology, classification, risk factors, signs and symptoms, diagnosis, and both pharmacological and non-pharmacological management strategies. The method used is a thematic narrative literature review based on scientific references and current clinical guidelines. Findings indicate that Alzheimer's disease is the most common form of dementia, with major risk factors including advanced age and vascular conditions. Diagnosis is established through neurobehavioral history, physical examination, cognitive tests (MMSE, MoCA, CDT), and neuroimaging. Treatment involves cholinesterase inhibitors (donepezil, rivastigmine), NMDA receptor antagonists (memantine), and non-pharmacological interventions such as cognitive therapies and a person-centered care approach. In conclusion, dementia management requires a multidisciplinary approach involving early detection, symptom control, and comprehensive support to improve patients’ quality of life.
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1. Ahmad, M., Kareem, O., Khushtar, M., Akbar, M., Haque, M., Iqubal, A., Haider, M., Pottoo, F., Abdulla, F., Al-Haidar, M., & Alhajri, N. (2022). Neuroinflammation: A Potential Risk For Dementia. International Journal Of Molecular Sciences, 23(2), 616. Https://Doi.Org/10.3390/Ijms23020616
2. Aranda, M. P., Kremer, I. N., Hinton, L., Zissimopoulos, J., Whitmer, R. A., Hummel, C. H., Trejo, L., & Fabius, C. D. (2021). Impact Of Dementia: Health Disparities, Population Trends, Care Interventions, And Economic Costs. Journal Of The American Geriatrics Society, 69(7), 1774–1783. Https://Doi.Org/10.1111/Jgs.17345
3. Basri, S. H. (2020). Gambaran Karakteristik Demensia Dan Tingkat Kemandirian Pasien Demensia Di Rs Błaszczyk, J. W. (2022). Pathogenesis Of Dementia. International Journal Of Molecular Sciences, 24(1), 543. Https://Doi.Org/10.3390/Ijms24010543
4. Broyles, I., Li, Q., Palmer, L., Dibello, M., Dey, J., Oliveira, I., & Lamont, H. (2023). Dementia's Unique Burden: Function And Health Care In The Last 4 Years Of Life. The Journals Of Gerontology: Series A, Biological Sciences And Medical Sciences. Https://Doi.Org/10.1093/Gerona/Glad003
5. Chouliaras, L., & O'Brien, J. T. (2023). The Use Of Neuroimaging Techniques In The Early And Differential Diagnosis Of Dementia. Molecular Psychiatry, 28, 4084–4097. Https://Doi.Org/10.1038/S41380-023-02215-8
6. Davis, D. H. J., Creavin, S. T., Yip, J. L. Y., Noel‐Storr, A. H., Brayne, C., & Cullum, S. (2021). Montreal Cognitive Assessment For The Detection Of Dementia. Cochrane Database Of Systematic Reviews, 2021(7), CD010775. Https://Doi.Org/10.1002/14651858.CD010775.Pub3
7. Dewi VT, Agung A, Laksmidewi AP. Manifestasi Klinis Dan Gambaran Pencitraan Struktural Dan Fungsional Berbagai Subtipe Demensia. CDK. 2023;50(11):594–9.
8. Fong, T. G., & Inouye, S. K. (2022). The Inter-Relationship Between Delirium And Dementia: The Importance Of Delirium Prevention. Nature Reviews Neurology, 18, 579–596. Https://Doi.Org/10.1038/S41582-022-00698-7
9. Koros, C., Stefanis, L., & Scarmeas, N. (2021). Parkinsonism And Dementia. Journal Of The Neurological Sciences, 433, 120015. Https://Doi.Org/10.1016/J.Jns.2021.120015
10. Kumalasari, A. N., Rahmayani, F., & Hamidi, S. (2018). Diagnosis Dan Pencegahan Perburukan Demensia Vaskular Pada Pasien Pasca Stroke. Jurnal Medula, 8(1), 25-32.
11. Kwentus, J., Hart, R., Lingon, N., Taylor, J., & Silverman, J. (2020). Alzheimer’s Disease. The American Journal Of Medicine, 81(1), 91–96. Https://Doi.Org/10.1093/Med/9780199644957.003.0033
12. Macoir, J. (2021). Dementia And Language. Oxford Bibliographies In Linguistics. Https://Doi.Org/10.1093/Obo/9780199772810-0275
Malaha, A., Jönsson, L., Seeher, K., Dua, T., Dielemann, J., Frisell, O., Cyhlarova, E., Nichols, E., Pedroza, P., Guerchet, M., Cataldi, R., Prince, 13. M., Wimo, A., & Knapp, M. (2023). The Worldwide Costs Of Dementia In 2019. Alzheimer's & Dementia, 19(12), 2865–2873. Https://Doi.Org/10.1002/Alz.12901
14. Mehta, R. I., & Schneider, J. A. (2021). What Is ‘Alzheimer's Disease’? The Neuropathological Heterogeneity Of Clinically Defined Alzheimer’s Dementia. Current Opinion In Neurology, 34(2), 237–245. Https://Doi.Org/10.1097/WCO.0000000000000912
15. Muliani, N. (2019). Pengaruh Pemberian Terapi Kenangan (Reminiscence Therapy) Terhadap Fungsi Kognitif Pada Lansia Di Pondok Lansia Al- Ishlah Malang (Doctoral Dissertation, Poltekkes RS Dr. Soepraoen).
16. Nordestgaard, L. T., Christoffersen, M., & Frikke-Schmidt, R. (2022). Shared Risk Factors Between Dementia And Atherosclerotic Cardiovascular Disease. International Journal Of Molecular Sciences, 23(17), 9777. Https://Doi.Org/10.3390/Ijms23179777
17. Oh, E. S. (2024). Dementia. Annals Of Internal Medicine, 177(3), ITC161–ITC176. Https://Doi.Org/10.7326/ANNALS-24-02207
18. Panduan Praktik Klinik Diagnosis Dan Penatalaksanaan Demensia. (2015). Perhimpunan Dokter Spesialis Saraf Indonesia.
19. Quinn C, Toms G, Rippon I, Nelis SM, Henderson C, Morris RG, Et Al. Positive Experiences In Dementia Care-Giving: Findings From The IDEAL Programme. Ageing Soc. 2024 May 29;44(5):1010–30
20. Sidarta E, Sari T, Mariyati S, Nataprawira D. Demensia: Patofisiologi, Faktor Resiko Dan Peran Inflamasi Dalam Perkembangan Penyakit. Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran. 2025;3(1):235–44.
21. Tarulli, A. (2020). Dementia. In Neurology (Pp. 65–84). Springer. Https://Doi.Org/10.1007/978-3-030-55598-6_4
22. Testo, A., Roundy, G., & Dumas, J. (2024). Cognitive Decline In Alzheimer's Disease. Current Topics In Behavioral Neurosciences. Https://Doi.Org/10.1007/7854_2024_527
23. Wahidin Sudirohusodo (Doctoral Dissertation, Universitas Hasanuddin).
24. Yang P, Bi G, Qi J, Wang X, Yang Y, Xu L. Multimodal Wearable Intelligence For Dementia Care In Healthcare 4.0: A Survey. Information Systems Frontiers. 2021;27:197–214.
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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.





